Some big changes are in store at Grey Sloan Memorial Hospital.
Can the hosts stop the Boys in Green from sealing back-to-back Grand Slams?
It's a huge derby clash at the Etihad Stadium.
Villa are aiming to keep their top-four challenge on track as they head to Kenilworth Road.
Jürgen Klopp's Reds look to increase their lead at the top of the EPL.
Two sides just a place apart in the EPL standings face off at St. James' Park.
The Seagulls travel to west London for a midtable match at Craven Cottage.
The Bees are looking to bounce back from Monday's defeat to West Ham as they host their west London neighbors.
Spurs look to get back to winning ways as they face the Eagles in this London derby.
The Blues and the Reds battle it out for the first piece of silverware in the English domestic season at Wembley Stadium.